Pain. Joint Locking, Swelling and restricted motion are very likely to be resolved after transplantation. Patello-femoral pain not be resolved. 

Safety Profile Inn Human Studies

Complications reported to date or complications which may occur but  have not yet been observed include: Adhesions post arthrotomy, Hypertrophic change of the graft, detachment of graft, Implant removal,  Septic knee, Synovitis, Deep vein thrombosis. 

No known adverse reaction is associated with the implant itself, though allergic reactions to serum components cannot be completely rated out. Transformation of cartilage denved  cells following implantation has mot  been observed, and is considered very unlikely.

Pathophysiology of Cartilage Defects

Lesions in articular cartilage fail to heal in adults and adolescents.  Larger articular cartilage defects often cause progressive degenerative  changes due to changes in joint biomechanics. The critical cut-off point  appears to be defects which are larger than one square centimeter.  Defect depth is also of importance, since thin defects which do not involve the entire thickness of the cartilage, do not progress. On the other  hand, defects which reach the subchondral bone often tend to progress.  The ultimate result of articular cartilage destruction is post traumatic  osteoarthritis.